Arp2/3 Complex
Actin-related protein 2/3 complex
The Arp2/3 complex is originally identified in Acanthamoeba and consists of seven proteins (actin-related proteins; Arp2 and Arp3, and Arp2/3 complex subunits; ARPC1-5) that are conserved in all eukaryotes, with the exception of some algae, microsporidia and protists. The complex plays an essential role in a wide variety of cellular processes including lamellipodia-mediated cell migration, endocytosis and phagocytosis, by virtue of its ability to generate branched actin filament networks.
Activation of Arp2/3 requires interaction with actin nucleation-promoting factors (NPFs). Regulation of Arp2/3 activity is achieved by endogenous inhibitory proteins through direct binding to Arp2/3 and competition with NPFs or by binding to Arp2/3-induced actin filaments and disassembly of branched actin networks. Arp2/3 inhibition has recently garnered more attention as it has been associated with attenuation of cancer progression, neurotoxic effects during drug abuse, and pathogen invasion of host cells.
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Arp2/3 Complex Related Products (45)
Related Products (45)
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Antibodies (99)
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Cytochalasin G
0 ImagesCat. No.: HY-N14568CAS No.: 54874-57-6Cytochalasin G has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis.
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Cytochalasin L
0 ImagesCat. No.: HY-N14569CAS No.: 79637-87-9Cytochalasin L has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis.
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CK-666 (Standard)
0 ImagesCat. No.: HY-16926RCAS No.: 442633-00-3CK-666 (Standard) is the analytical standard of CK-666 (HY-16926). This product is intended for research and analytical applications. CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocKing movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
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Cytochalasin D (Standard)
0 ImagesCat. No.: HY-N6682RCAS No.: 22144-77-0Synonyms: Zygosporin A (Standard); NSC 209835 (Standard)Cytochalasin D (Standard) is the analytical standard of Cytochalasin D (HY-N6682). This product is intended for research and analytical applications. Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap.
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Cytochalasin M
0 ImagesCat. No.: HY-N14696CAS No.: 79648-73-0Cytochalasin M has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis.
